Interleukin-6

Interleukin-6 (bahasa Inggris: Interleukin 6, Interferon beta-2, IFNB2, B cell differentiation factor, B cell stimulatory factor 2, BSF2, Hepatocyte stimulatory factor, HSF, Hybridoma growth factor, HGF, IL-6) adalah sitokina yang disekresi dari jaringan tubuh ke dalam plasma darah, terutama pada fase infeksi akut atau kronis, dan menginduksi respon peradangan transkriptis melalui pencerap IL-6 RA, menginduksi maturasi sel B. dan pencerap gp130.

IL6
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 4O9H, 1ALU, 1IL6, 1P9M, 2IL6, 4CNI, 4J4L, 4NI7, 4NI9, 4ZS7
Pengidentifikasi
Alias	IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
ID eksternal	OMIM: 147620 MGI: 96559 HomoloGene: 502 GeneCards: IL6
Lokasi gen (Tikus) Kr. Kromosom 5 (tikus) Pita 5 B1|5 15.7 cM Awal 30,218,112 bp Akhir 30,224,979 bp
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • cytokine activity • growth factor activity • interleukin-6 receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma Komponen seluler • extracellular region • interleukin-6 receptor complex • extracellular space • endoplasmic reticulum lumen Proses biologis • regulation of angiogenesis • positive regulation of translation • platelet activation • humoral immune response • defense response to virus • response to peptidoglycan • neuron projection development • GO:0051637 defense response to Gram-positive bacterium • negative regulation of fat cell differentiation • positive regulation of peptidyl-serine phosphorylation • positive regulation of leukocyte chemotaxis • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of acute inflammatory response • inflammatory response • negative regulation of collagen biosynthetic process • positive regulation of MAPK cascade • hepatic immune response • monocyte chemotaxis • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • positive regulation of osteoblast differentiation • positive regulation of NF-kappaB transcription factor activity • acute-phase response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun • regulation of vascular endothelial growth factor production • positive regulation of chemokine production • negative regulation of lipid storage • neutrophil mediated immunity • positive regulation of smooth muscle cell proliferation • positive regulation of type B pancreatic cell apoptotic process • response to glucocorticoid • GO:0051636 defense response to Gram-negative bacterium • positive regulation of cell population proliferation • positive regulation of apoptotic process • positive regulation of B cell activation • modifikasi pascatranslasi • regulation of signaling receptor activity • positive regulation of tyrosine phosphorylation of STAT protein • neutrophil apoptotic process • negative regulation of cell population proliferation • GO:1901313 positive regulation of gene expression • endocrine pancreas development • negative regulation of bone resorption • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • glucagon secretion • cellular response to hydrogen peroxide • cellular response to lipopolysaccharide • T-helper 17 cell lineage commitment • positive regulation of T-helper 2 cell cytokine production • negative regulation of interleukin-1-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • GO:0072468 signal transduction Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	3569	16193
Ensembl	ENSG00000136244	ENSMUSG00000025746
UniProt	P05231	P08505
RefSeq (mRNA)	NM_000600 NM_001318095 NM_001371096	NM_031168 NM_001314054
RefSeq (protein)	NP_000591 NP_001305024 NP_001358025	NP_001300983 NP_112445
Lokasi (UCSC)	n/a	Chr 5: 30.22 – 30.22 Mb
Pencarian PubMed
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus