Interleukin-15

IL15
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	2XQB, 2Z3Q, 2Z3R, 4GS7
Pengidentifikasi
Alias	IL15, IL-15, interleukin 15
ID eksternal	OMIM: 600554 MGI: 103014 HomoloGene: 487 GeneCards: IL15
Lokasi gen (Tikus)
Kr.	Kromosom 8 (tikus)
Akhir	83,129,851 bp
Pola ekspresi RNA
	; ;
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• GO:0001948, GO:0016582 Ikatan protein plasma; • GO:0005145 cytokine receptor binding; • cytokine activity;
Komponen seluler	• Inti sel; • integral component of plasma membrane; • badan Golgi; • endosom; • nucleoplasm; • membran; • cell surface; • extracellular region; • extracellular space; • sitoplasma; • sitosol; • nuclear speck;
Proses biologis	• negative regulation of smooth muscle cell proliferation; • cell maturation; • extrathymic T cell selection; • positive regulation of T cell proliferation; • regulation of defense response to virus by host; • positive regulation of inflammatory response; • response to nutrient levels; • positive regulation of protein O-linked glycosylation; • positive regulation of interleukin-17 production; • hyaluronan metabolic process; • positive regulation of natural killer cell differentiation; • regulation of T cell differentiation; • positive regulation of tissue remodeling; • cellular response to vitamin D; • lymph node development; • natural killer cell differentiation; • positive regulation of natural killer cell proliferation; • cell-cell signaling; • skeletal muscle atrophy; • GO:0072468 signal transduction; • GO:0010260 penuaan; • NK T cell proliferation; • positive regulation of immune response; • inflammatory response; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 respons imun; • positive regulation of cell population proliferation; • tyrosine phosphorylation of STAT protein; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • interleukin-15-mediated signaling pathway; • neutrophil activation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of phagocytosis; • negative regulation of cold-induced thermogenesis; • macrophage differentiation;
	Sumber:Amigo / QuickGO
Ortolog
	3600
	16168
	ENSG00000164136
	ENSMUSG00000031712
	P40933
	P48346
	NM_000585; NM_172174; NM_172175
	NM_001254747; NM_008357
	NP_000576; NP_751915
	NP_001241676; NP_032383
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Interleukin-15, IL-15 (bahasa Inggris: MGC9721) adalah sitokin yang disekresikan oleh beragam sel dan jaringan tubuh yang berperan dalam aktivasi dan proliferasi sel NK dan sel T.^[4] IL-15 mempunyai beberapa kemiripan dengan IL-2 dalam hal aktivitas seluler.^[5] Kedua sitokina ini mengikat sub-unit reseptor hematopoietin yang sama, walaupun masing-masing memiliki fungsi yang berbeda. Rasio dari sel T memori dengan ekspresi CD8 dikendalikan oleh rasio antara IL-15 dan IL-2.

IL-15 juga menginduksi aktivasi enzim JAK kinase, selain aktivator transkripsi STAT-3, STAT-5, STAT-6, dan fosforilasi.

Pada model tikus, IL-15 meningkatkan ekspresi inhibitor apoptosis BCL2L1/BCL-x(L).

Defisiensi pada IL-15 ditemukan pada pasien dengan rheumatoid arthritis, penyakit radang usus dan penyakit yang disebabkan infeksi retrovirus seperti HIV dan HTLV-I.^[6]

Referensi

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031712 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ (Inggris) "IL15 interleukin 15 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-08.
^ Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, et al. (1994). "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor". Science. 264 (5161): 965–8. PMID 8178155.
^ Waldmann TA, Tagaya Y (1999). "The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens". Annu Rev Immunol. 17: 19–49. PMID 10358752.

Artikel bertopik imunologi ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031712 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] (Inggris) "IL15 interleukin 15 [ Homo sapiens ]". Entrez Gene. Diakses tanggal 2010-06-08.

[5] Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, et al. (1994). "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor". Science. 264 (5161): 965–8. PMID 8178155.

[6] Waldmann TA, Tagaya Y (1999). "The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens". Annu Rev Immunol. 17: 19–49. PMID 10358752.

[4]

[5]

[1]

[2]

[3]

[6]