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glutamate—ammonia ligase
MN MN ADP PPQ.png
Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding sites are yellow and orange; ADP is pink; phosphinothricin is blue.[1]
Pengidentifikasi
Nomor EC6.3.1.2
Nomor CAS9023-70-5
Basis data
IntEnztinjauan IntEnz
BRENDAentri BRENDA
ExPASytinjauan NiceZyme
KEGGentri KEGG
MetaCycjalur metabolik
PRIAMprofil
Struktur PDBRCSB PDB PDBe PDBsum
Ontologi GenAmiGO / EGO
Glutamine synthetase,
beta-Grasp domain
Identifikasi
SimbolGln-synt_N
PfamPF03951
InterProIPR008147
PROSITEPDOC00162
SCOP2gls
SUPERFAMILY2gls
Glutamine synthetase,
catalytic domain
PDB 2gls EBI.jpg
12-subunit enzyme glutamine synthetase from Salmonella typhimurium.[2]
Identifikasi
SimbolGln-synt_C
PfamPF00120
Klan PfamCL0286
InterProIPR008146
PROSITEPDOC00162
SCOP2gls
SUPERFAMILY2gls
glutamate-ammonia ligase (glutamine synthetase)
Pengenal
Simbol GLUL
Simbol alternatif GLNS
Entrez 2752
HUGO 4341
OMIM 138290
PDB 2qc8
RefSeq NM_002065
UniProt P15104
Data lain
EC number 6.3.1.2
Locus Chr. 1 q31

Glutamin sintetase (GS) (EC 6.3.1.2)[3] adalah enzim yang memainkan peran penting dalam metabolisme nitrogen dengan mengkatalisis kondensasi glutamat dan amonia untuk membentuk glutamin:

Glutamat + ATP + NH3 → Glutamin + ADP + fosfat

Glutamine Synthetase reaction.

ReferensiSunting

  1. ^ PDB: 1FPY​; Gill HS, Eisenberg D (February 2001). "The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition". Biochemistry. 40 (7): 1903–12. doi:10.1021/bi002438h. PMID 11329256. 
  2. ^ PDB: 2GLS​; Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D (October 1989). "Refined atomic model of glutamine synthetase at 3.5 A resolution". J. Biol. Chem. 264 (30): 17681–90. PMID 2572586. 
  3. ^ Eisenberg D, Almassy RJ, Janson CA, Chapman MS, Suh SW, Cascio D, Smith WW (1987). "Some evolutionary relationships of the primary biological catalysts glutamine synthetase and RuBisCO". Cold Spring Harb. Symp. Quant. Biol. 52: 483–90. doi:10.1101/sqb.1987.052.01.055. PMID 2900091. 

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