Latrofilin 2

Latrofilin 2 adalah protein yang pada manusia disandi oleh gen ADGRL2.

ADGRL2
Pengidentifikasi
Alias	ADGRL2, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
ID eksternal	OMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2
Lokasi gen (Tikus) Kr. Kromosom 3 (tikus) Pita 3|3 H3 Awal 148,815,583 bp Akhir 148,990,555 bp
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • G protein-coupled receptor activity • transmembrane signaling receptor activity • latrotoxin receptor activity • signal transducer activity • carbohydrate binding Komponen seluler • komponen integral membran • membran • intracellular anatomical structure • integral component of plasma membrane • neuron projection Proses biologis • G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • GO:0072468 signal transduction • adenylate cyclase-activating G protein-coupled receptor signaling pathway • brain development Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	23266	99633
Ensembl	ENSG00000117114	ENSMUSG00000028184
UniProt	O95490	Q8JZZ7
RefSeq (mRNA)	NM_001297704 NM_001297705 NM_001297706 NM_012302 NM_001330645 NM_001350698 NM_001350699 NM_001366002 NM_001366003 NM_001366004 NM_001366005 NM_001366006 NM_001366007 NM_001366008 NM_001366009 NM_001393349 NM_001393350 NM_001393351 NM_001393352 NM_001393353 NM_001393354	NM_001081298
RefSeq (protein)	NP_001284633 NP_001284634 NP_001284635 NP_001317574 NP_036434 NP_001337627 NP_001337628 NP_001352931 NP_001352932 NP_001352933 NP_001352934 NP_001352935 NP_001352936 NP_001352937 NP_001352938	NP_001074767 NP_001392915 NP_001392916 NP_001392917 NP_001392918 NP_001392919 NP_001392920 NP_001392921 NP_001392922 NP_001392923 NP_001392924 NP_001392925 NP_001392926 NP_001392927 NP_001392928 NP_001392929 NP_001392930 NP_001392931 NP_001392932 NP_001392933 NP_001392934 NP_001392935 NP_001392936 NP_001392937 NP_001392938 NP_001392939 NP_001392940 NP_001392947 NP_001392948
Lokasi (UCSC)	n/a	Chr 3: 148.82 – 148.99 Mb
Pencarian PubMed
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Gen ini menyandi anggota subfamili latrofilin reseptor terhubung protein G (GPCR). Latrofilin dapat berfungsi dalam adhesi sel dan transduksi sinyal. Dalam percobaan dengan spesies non-manusia, pembelahan proteolitik endogen dalam GPS yang kaya sistein (situs proteolisis GPCR) menghasilkan dua subunit yaitu fragmen N-terminal dan fragmen C-terminal (subunit dengan kemiripan dengan keluarga sekretin/kalsitonin) dan tidak terikat secara kovalen pada membran sel. Sementara beberapa varian transkrip telah dijelaskan, validitas biologis hanya satu yang telah ditentukan.

Lihat juga

• Reseptor berpasangan protein G adhesi

Bacaan lebih lanjut

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• Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi:10.1186/gb-2007-8-4-r64. PMC 1896007 . PMID 17456239.