Prostasiklin

Prostasiklin
Nama sistematis (IUPAC)
	(Z)-5-[(4R,5R)-5-Hydroxy-4-((S,E)-3-hydroxyoct-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic acid
Data klinis
AHFS/Drugs.com	monograph
Kat. kehamilan	?
Status hukum	?
Data farmakokinetik
Waktu paruh	42 seconds
Pengenal
Nomor CAS	35121-78-9
Kode ATC	B01AC09
PubChem	CID 5282411
Ligan IUPHAR	1915
DrugBank	DB01240
ChemSpider	4445566
ChEMBL	CHEMBL962
Data kimia
Rumus	C20H32O5
Massa mol.	352.465 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 ; Key:KAQKFAOMNZTLHT-OZUDYXHBSA-N ;

Prostasiklin (juga disebut prostaglandin I2 atau PGI₂) adalah sejenis prostaglandin yang merupakan vasodilator kuat dan juga dapat menghambat aktivasi keping darah.^[1] Jika digunakan sebagai obat, prostasiklin juga dikenal dengan sebutan epoprostenol.^[2]^[3]

Prostasiklin dapat dimanfaatkan untuk menangani hipertensi paru.^[4]

Referensi sunting

^ Pathologic Basis of Disease, Robbins and Cotran, 8th ed. Saunders Philadelphia 2010
^ "epoprostenol" di Kamus Medis Dorland
^ Kermode J, Butt W, Shann F (August 1991). "Comparison between prostaglandin E1 and epoprostenol (prostacyclin) in infants after heart surgery". British Heart Journal. 66 (2): 175–8. doi:10.1136/hrt.66.2.175. PMC 1024613  . PMID 1883670.
^ "Iloprost Monograph for Professionals". AHFS. Diakses tanggal 29 December 2017.

[1] Pathologic Basis of Disease, Robbins and Cotran, 8th ed. Saunders Philadelphia 2010

[2] "epoprostenol" di Kamus Medis Dorland

[pmid1883670-3] Kermode J, Butt W, Shann F (August 1991). "Comparison between prostaglandin E1 and epoprostenol (prostacyclin) in infants after heart surgery". British Heart Journal. 66 (2): 175–8. doi:10.1136/hrt.66.2.175. PMC 1024613  . PMID 1883670.

[4] "Iloprost Monograph for Professionals". AHFS. Diakses tanggal 29 December 2017.

[1]

[2]

[3]

[4]



Nama sistematis (IUPAC)
(Z)-5-[(4R,5R)-5-Hydroxy-4-((S,E)-3-hydroxyoct-1-enyl)hexahydro-2H-cyclopenta[b]furan-2-ylidene]pentanoic acid
Data klinis
AHFS/Drugs.com	monograph
Kat. kehamilan	?
Status hukum	?
Data farmakokinetik
Waktu paruh	42 seconds
Pengenal
Nomor CAS	35121-78-9^Y
Kode ATC	B01AC09
PubChem	CID 5282411
Ligan IUPHAR	1915
DrugBank	DB01240
ChemSpider	4445566^N
ChEMBL	CHEMBL962^N
Data kimia
Rumus	C₂₀H₃₂O₅
Massa mol.	352.465 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1^N Key:KAQKFAOMNZTLHT-OZUDYXHBSA-N^N