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Maternal embryonic leucine zipper kinase (MELK) adalah enzim yang pada manusia disandi oleh gen MELK.[2][3][4] MELK adalah serin/treonin kinase milik keluarga protein AMPK/snf1 kinase. MELK pertama kali diidentifikasi hadir sebagai mRNA maternal pada embrio tikus.[5] MELK telah terbukti terlibat dalam perkembangan melalui siklus sel, mungkin terkait dengan interaksinya dengan CDC25B.[6]

MELK
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMELK, HPK38, maternal embryonic leucine zipper kinase
External IDsOMIM: 607025 HomoloGene: 32111 GeneCards: MELK
EC number2.7.10.2
RNA expression pattern
PBB GE MELK 204825 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Ekspresi MELK meningkat pada sejumlah kanker dan merupakan target penelitian aktif untuk penghambatan farmakologis.[7]

InteraksiSunting

MELK telah terbukti berinteraksi dengan CDC25B.[8]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. February 1996. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  3. ^ "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. June 1997. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115. 
  4. ^ "Entrez Gene: MELK maternal embryonic leucine zipper kinase". 
  5. ^ "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. August 1999. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823. 
  6. ^ "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. August 2005. doi:10.1083/jcb.200412115. PMC 2171475 . PMID 16061694. 
  7. ^ "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. November 2005. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996. 
  8. ^ "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. October 2002. doi:10.1038/sj.onc.1205870. PMID 12400006.