Pada tahun 20172014, Kvemo Kartli memiliki penduduk sebanyak 423.986 jiwa, dengan komposisi etnis sebagai berikut.<ref>{{cite web|url=[http://wwwpop-stat.geostatmashke.georg/cms/site_images/_files/english/census/2014/17_Total%20population%20by%20regions%20and%20ethnicitygeorgia-ethnic-loc2014.xls|title=Totalhtm population by regions and ethnicity|publisher=National Statistics Office of Georgia|accessdate=5 Aug 2017|archivegeorgia-date=2017ethnic-02-23|archive-url=https://web.archive.org/web/20170223050138/http://www.geostat.ge/cms/site_images/_files/english/census/2014/17_Total%20population%20by%20regions%20and%20ethnicity.xls|dead-url=yes}}]</ref>
