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Karsinogen kimiawi yang pertama kali diidentifikasi adalah senyawa hidrokarbon aromatik polisiklik.<ref>{{en}}{{cite book
| title = Holland-Frei Cancer medicine - Carcinogen Metabolism
| author = Kufe, Donald W.; Pollock, Raphael E.; Weichselbaum, Ralph R.; Bast, Robert C., Jr.; Gansler, Ted S.; Holland, James F.; Frei III, Emil.
| work = Dana-Farber Cancer Institute, Harvard Medical School Boston, Department of Surgical Oncology, University of Texas, MD Anderson Cancer Center, Department of Radiation and Cellular Oncology, University of Chicago Hospital, Chicago Tumor Institute, University of Chicago Chicago, University of Texas, MD Anderson Cancer Center, Houston, American Cancer Society, Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine New York
| isbn = 1-55009-213-8
| edition = 6
| year = 2003
| page =
| publisher = Hamilton on BC Decker Inc.,
| url = http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed6&part=A5000
| accessdate = 2010-07-07
}}</ref>
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