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CD40 (kluster diferensiasi 40) adalah protein yang dapat ditemui pada sel penyaji antigen, dan protein ini dibutuhkan untuk mengaktivasi sel tersebut. Reseptor protein yang disandikan oleh gen ini merupakan bagian dari superfamili reseptor TNF. Reseptor ini penting dalam menengahi berbagai macam respons imun, termasuk pembentukan pusat germinal.[1]

CD40 diketahui dapat berinteraksi dengan TRAF2,[2][3][4] TRAF3,[3][5][6][7] TRAF6,[3][7] TRAF5[3][8] dan TTRAP.[9]

Molekul CD40 merupakan target potensial untuk imunoterapi kanker. Terdapat sejumlah uji coba klinis yang sedang berlangsung dan juga yang telah dituntaskan dengan antibodi monoklonal anti-CD40 yang dipakai untuk mengaktivasi respons sel T anti-tumor lewat aktivasi sel-sel dendritik.[10]

ReferensiSunting

  1. ^ Grewal IS, Flavell RA (1998). "CD40 and CD154 in cell-mediated immunity". Annual Review of Immunology. 16: 111–35. doi:10.1146/annurev.immunol.16.1.111. PMID 9597126. 
  2. ^ McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T (July 1999). "Crystallographic analysis of CD40 recognition and signaling by human TRAF2". Proceedings of the National Academy of Sciences of the United States of America. 96 (15): 8408–13. doi:10.1073/pnas.96.15.8408. PMC 17529 . PMID 10411888. 
  3. ^ a b c d Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J (February 1999). "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. PMC 15446 . PMID 9990007. 
  4. ^ Malinin NL, Boldin MP, Kovalenko AV, Wallach D (February 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature. 385 (6616): 540–4. doi:10.1038/385540a0. PMID 9020361. 
  5. ^ Hu HM, O'Rourke K, Boguski MS, Dixit VM (December 1994). "A novel RING finger protein interacts with the cytoplasmic domain of CD40". The Journal of Biological Chemistry. 269 (48): 30069–72. PMID 7527023. 
  6. ^ Ni CZ, Welsh K, Leo E, Chiou CK, Wu H, Reed JC, Ely KR (September 2000). "Molecular basis for CD40 signaling mediated by TRAF3". Proceedings of the National Academy of Sciences of the United States of America. 97 (19): 10395–9. doi:10.1073/pnas.97.19.10395. PMC 27035 . PMID 10984535. 
  7. ^ a b Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (December 1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". The EMBO Journal. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295 . PMID 9384571. 
  8. ^ Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (September 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proceedings of the National Academy of Sciences of the United States of America. 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. PMC 38446 . PMID 8790348. 
  9. ^ Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE (June 2000). "TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation". The Journal of Biological Chemistry. 275 (24): 18586–93. doi:10.1074/jbc.M000531200. PMID 10764746. 
  10. ^ Vonderheide RH (April 2018). "The Immune Revolution: A Case for Priming, Not Checkpoint". Cancer Cell. 33 (4): 563–569. doi:10.1016/j.ccell.2018.03.008. PMC 5898647 . PMID 29634944.