Bisakodil

Bisakodil
Nama sistematis (IUPAC)
	(pyridin-2-ylmethanediyl)dibenzene-4,1-diyl diacetate ; OR ; 4,4'-(pyridin-2-ylmethylene)bis(4,1-phenylene) diacetate
Data klinis
Nama dagang	Fleet, Purga, Dulcolax, Brooklax, others
AHFS/Drugs.com	monograph
MedlinePlus	a601027
Kat. kehamilan	B
Status hukum	OTC
Rute	By mouth or rectal
Data farmakokinetik
Bioavailabilitas	15%
Metabolisme	Liver (CYP450-mediated)
Waktu paruh	16 Hours
Ekskresi	primarily in the feces, systemically absorbed drug is excreted in the urine
Pengenal
Nomor CAS	603-50-9
Kode ATC	A06AB02 A06AG02
PubChem	CID 2391
DrugBank	DB09020
ChemSpider	2299
UNII	10X0709Y6I
KEGG	D00245
ChEMBL	CHEMBL942
Data kimia
Rumus	C22H19NO4
SMILES	eMolecules & PubChem
	InChI InChI=1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3 ; Key:KHOITXIGCFIULA-UHFFFAOYSA-N ;

Bisakodil adalah senyawa organik yang digunakan untuk obat pencahar stimulan. Obat bisakodil bekerja langsung pada usus besar untuk menghasilkan gerakan usus. Pemberian obat bisakodil biasanya diresepkan untuk menghilangkan konstipasi episodik dan kronis dan untuk pengelolaan disfungsi usus neurogenik, serta bagian dari persiapan usus sebelum pemeriksaan medis, seperti untuk kolonoskopi.^[1]^[2]

Bisakodil adalah turunan dari trifenilmetana. Ini pertama kali digunakan sebagai pencahar pada tahun 1953 karena kemiripan strukturalnya dengan fenolftalein.^[3]^[4]

Referensi sunting

^ Wexner, Steven D.; Force, Task; Beck, David E.; Baron, Todd H.; Fanelli, Robert D.; Hyman, Neil; Shen, Bo; Wasco, Kevin E. (2006-06). "A consensus document on bowel preparation before colonoscopy: Prepared by a Task Force From The American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)". Gastrointestinal Endoscopy. 63 (7): 894–909. doi:10.1016/j.gie.2006.03.918. ISSN 0016-5107.
^ Wald, Arnold (2016-01-12). "Constipation: Advances in Diagnosis and Treatment". JAMA. 315 (2): 185–191. doi:10.1001/jama.2015.16994. ISSN 1538-3598. PMID 26757467.
^ Stiens, Steven A.; Luttrel, William; Binard, Joseph E. (1998-11). "Polyethylene glycol versus vegetable oil based bisacodyl suppositories to initiate side-lying bowel care: A clinical trial in persons with spinal cord injury". Spinal Cord (dalam bahasa Inggris). 36 (11): 777–781. doi:10.1038/sj.sc.3100702. ISSN 1476-5624.
^ Evans, I. Lynn (1964-06-01). "The use of Bisacodyl suppositories in preparation for sigmoidoscopy". Gut (dalam bahasa Inggris). 5 (3): 271–273. doi:10.1136/gut.5.3.271. ISSN 0017-5749. PMC 1552120  . PMID 14178715. Pemeliharaan CS1: Format PMC (link)

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[1] Wexner, Steven D.; Force, Task; Beck, David E.; Baron, Todd H.; Fanelli, Robert D.; Hyman, Neil; Shen, Bo; Wasco, Kevin E. (2006-06). "A consensus document on bowel preparation before colonoscopy: Prepared by a Task Force From The American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES)". Gastrointestinal Endoscopy. 63 (7): 894–909. doi:10.1016/j.gie.2006.03.918. ISSN 0016-5107.

[2] Wald, Arnold (2016-01-12). "Constipation: Advances in Diagnosis and Treatment". JAMA. 315 (2): 185–191. doi:10.1001/jama.2015.16994. ISSN 1538-3598. PMID 26757467.

[3] Stiens, Steven A.; Luttrel, William; Binard, Joseph E. (1998-11). "Polyethylene glycol versus vegetable oil based bisacodyl suppositories to initiate side-lying bowel care: A clinical trial in persons with spinal cord injury". Spinal Cord (dalam bahasa Inggris). 36 (11): 777–781. doi:10.1038/sj.sc.3100702. ISSN 1476-5624.

[4] Evans, I. Lynn (1964-06-01). "The use of Bisacodyl suppositories in preparation for sigmoidoscopy". Gut (dalam bahasa Inggris). 5 (3): 271–273. doi:10.1136/gut.5.3.271. ISSN 0017-5749. PMC 1552120  . PMID 14178715. Pemeliharaan CS1: Format PMC (link)

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