Serotonin: Perbedaan revisi

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<tr><th colspan="2" align=center bgcolor="#cccccc">'''Serotonin'''</th></tr>
<tr><td colspan="2" align="center">[[Berkas:Serotonin-skeletal.png|145px|Struktur kimia serotonin]][[Berkas:Serotonin-3D-vdW.png|145px|Struktur tiga dimensi ]]</td></tr>
<tr><td>[[Nomenklatur IUPAC|Nama kimia]]</td><td>5-Hidroksitriptamina, atau{{br}}3-(2-aminoetil)-1''H''-indol-5-ol</td></tr>
In the body, serotonin is synthesized from the [[amino acid]] [[tryptophan]] by a short [[metabolic pathway]] consisting of two [[enzyme]]s — TPH([[Tryptophan hydroxylase 1|1]],[[Tryptophan hydroxylase 2|2]]) and [[Aromatic-L-amino-acid decarboxylase|DDC]]. TPH1 [[chemical reaction|reaction]] controls the flux through the pathway.
[[Berkas:5htsynt_2.png|frame|left|403px|The pathway for the synthesis of serotonin from Trp]]<br style="clear: both;" />
| chapterurl =
| quote = In 1964, Dahlstrom and Fuxe (discussed in [2]), using the Falck-Hillarp technique of histofluorescence, observed that the majority of serotonergic soma are found in cell body groups, which previously had been designated as the raphe nuclei.
}}</ref> These neurons are grouped into about nine pairs, distributed along the entire length of the brainstem. 5-HT is thought to be released from serotonergic varicosities into the extra neuronal space, in other words from swellings (varicosities) along the axon, rather than from synaptic terminal buttons (in the manner of classical neurotransmission). From here it is free to diffuse over a relatively large region of space (>20µm) and activate [[5-HT receptor]]s located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons.
Serotonergic action is terminated primarily via [[reuptake|uptake]] of 5-HT from the synapse. This is through the specific [[monoamine transporter]] for 5-HT, [[Serotonin transporter|5-HT reuptake transporter]], on the presynaptic neuron. Various agents can inhibit 5-HT reuptake including [[MDMA]] (most commonly known by the street name ecstasy or XTC), [[cocaine]], [[tricyclic antidepressants]] (TCAs) and [[selective serotonin reuptake inhibitor]]s (SSRIs).
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