Sebagai pencegahan, [[Federal Aviation Administration|FAA]] membatasi ruang udara di sekitar Boston dan mengeluarkan perintah penghentian aktivitas di [[Bandar Udara Internasional Logan Boston]].<ref>{{cite news|title=At least 2 dead, 23 injured in explosions reported at Boston Marathon|url=http://www.pri.org/stories/politics-society/government/at-least-2-dead-23-injured-in-explosions-reported-at-boston-marathon-13512.html|publisher=PRI International|accessdate=April 15, 2013}}</ref><ref>http://www.wmbfnews.com/story/21982414/2-dead-64-hurt-from-boston-marathon-bomb-blasts</ref>
[[Jaksa UmumAgung Amerika Serikat]] [[Eric Holder]] memerintahkan agar "semua sumber daya" [[Departemen Kehakiman Amerika Serikat]] dimanfaatkan untuk menyelidiki ledakan ini.<ref>{{cite web|title=Deadly bombs strike Boston Marathon; authorities discover more bombs|author=Levs, Josh|url=http://edition.cnn.com/2013/04/15/us/boston-marathon-explosions/?hpt=us_c1|publisher=[[CNN]]|date=April 15, 2013|accessdate=April 15, 2013}}</ref> Di New York City, kendaraan kontraterorisme dikerahkan ke tempat-tempat penting di [[Manhattan]].<ref name="Fox News"/> [[Kepolisian New York]] meningkatkan keamanan di hotel-hotel dan tempat lain.<ref>{{cite web|title=Boston Marathon Blasts Kill 2, Police Say|url=http://www.nytimes.com/2013/04/16/us/explosions-reported-at-site-of-boston-marathon.html|publisher=[[New York Times]]|date=April 15, 2013|accessdate=April 15, 2013}}</ref> Keamanan juga ditingkatkan di [[Washington, D.C.]] dan [[Gedung Putih]] dievakuasi,<ref>{{cite web|title=Deadly bombs strike Boston Marathon; authorities discover more bombs|author=Levs, Josh|url=http://edition.cnn.com/2013/04/15/us/boston-marathon-explosions/?hpt=us_c1|publisher=[[CNN]]|date=April 15, 2013|accessdate=April 15, 2013}}</ref> sedangkan [[Pennsylvania Avenue]] ditutup oleh [[United States Secret Service]].<ref>{{cite web|title=Obama Calls Mass. Officials After Explosions|url=http://nation.time.com/2013/04/15/obama-notified-about-explosions-at-boston-marathon/|publisher=[[TIME]]|date=April 15, 2013|accessdate=April 15, 2013}}</ref>
[[Google Person Finder]] mengaktifkan layanan bencana ''Boston Marathon Explosions'' agar pengguna bisa mencari informasi seputar orang hilang.<ref>{{cite web|title=Google Person Finder: Boston Marathon Explosions|url=http://google.org/personfinder/2013-boston-explosions/|date=April 15, 2013|accessdate=April 15, 2013}}</ref>
