Pertandingan pertama akan dilaksanakan pada 7 Maret sementara pertandingan kedua akan dilaksanakan pada 14 Maret 2013.
{{TwoLeg start}}
{{TwoLegResult|[[FC Viktoria Plzeň|Viktoria Plzeň]] {{flagicon|CZE}}||1|{{flagicon|TUR}} [[Fenerbahçe S.K. (football)|Fenerbahçe]]|TUR|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Viktoria Plzeň v Fenerbahçe|0–1]]|[[Babak gugur Liga Eropa UEFA 2012–13#Fenerbahçe v Viktoria Plzeň|14 Maret]]}}
{{TwoLegResult|[[S.L. Benfica|Benfica]] {{flagicon|POR}}||2|{{flagicon|FRA}} [[FC Girondins de Bordeaux|Bordeaux]]|FRA|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Benfica v Bordeaux|1–0]]|[[Babak gugur Liga Eropa UEFA 2012–13#Bordeaux v Benfica|14 Maret]]}}
{{TwoLegResult|[[FC Anzhi Makhachkala|Anzhi Makhachkala]] {{flagicon|RUS}}||3|[[Newcastle United F.C.|Newcastle United]]|ENG|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Anzhi Makhachkala v Newcastle United|0–0]]|[[Babak gugur Liga Eropa UEFA 2012–13#Newcastle United v Anzhi Makhachkala|14 Maret]]}}
{{TwoLegResult|[[VfB Stuttgart|Stuttgart]]|GER|4|[[S.S. Lazio|Lazio]]|ITA|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Stuttgart v Lazio|0–2]]|[[Babak gugur Liga Eropa UEFA 2012–13#Lazio v Stuttgart|14 Maret]]}}
{{TwoLegResult|[[Tottenham Hotspur F.C.|Tottenham Hotspur]]|ENG|5|[[Inter Milan|Internazionale]]|ITA|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Tottenham Hotspur v Internazionale|3–0]]|[[Babak gugur Liga Eropa UEFA 2012–13#Internazionale v Tottenham Hotspur|14 Maret]]}}
{{TwoLegResult|[[Levante UD|Levante]] {{flagicon|ESP}}||6|[[FC Rubin Kazan|Rubin Kazan]]|RUS|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Levante v Rubin Kazan|0–0]]|[[Babak gugur Liga Eropa UEFA 2012–13#Rubin Kazan v Levante|14 Maret]]}}
{{TwoLegResult|[[FC Basel|Basel]]|SUI|7|{{flagicon|RUS}} [[FC Zenit Saint Petersburg|Zenit St. Petersburg]]|RUS|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Basel v Zenit St. Petersburg|2–0]]|[[Babak gugur Liga Eropa UEFA 2012–13#Zenit St. Petersburg v Basel|14 Maret]]}}
{{TwoLegResult|[[FC Steaua București|Steaua București]] {{flagicon|ROU}}||8|{{flagicon|ENG}} [[Chelsea F.C.|Chelsea]]|ENG|7[[Babak Maretgugur Liga Eropa UEFA 2012–13#Steaua București v Chelsea|1–0]]|[[Babak gugur Liga Eropa UEFA 2012–13#Chelsea v Steaua București|14 Maret]]}}
