Protein Kinase B: Perbedaan antara revisi
Konten dihapus Konten ditambahkan
dev |
dev |
||
Baris 11:
| accessdate = 2011-07-13
| work = Department of Experimental Therapeutics, Department of Molecular & Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital; Yong Liao dan Mien-Chie Hung
}}</ref> dan merupakan [[substrat]] utama bagi [[kinase fosfatidil inositol-3|PI3K]].<ref name="hem-ref" /> [[Senyawa organik|Senyawa]] [[fosfoinositida]] yang diproduksi oleh [[kinase fosfatidil inositol-3|PI3K]], yaitu [[fosfatidil inositol 3,4-bifosfat]] dan [[fosfatidil inositol 3,4,5-trisfosfat]], akan mengikat pada domain ''pleckstrin homology'' (PH) dari Akt, hingga memungkinan translokasi Akt ke dalam [[sitoplasma]] untuk diaktivasi oleh [[PDK-1]] dengan [[fosforilasi]] pada residu [[treonina|Thr]]-308 dan [[serina|Ser]]-473.<ref>{{en}}{{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832988
| title = A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation
| accessdate = 2011-07-13
| work = Departments of ‡Molecular Oncology, Thoracic Oncology, and Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital; Donghwa Kim, Mei Sun, Lili He, Qing-Hua Zhou, Jun Chen, Xia-Meng Sun, Gerold Bepler, Said M. Sebti, dan Jin Q. Cheng
}}</ref>
== Rujukan ==
| |||