Kompleks piruvat dehidrogenase: Perbedaan antara revisi
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'''Kompleks piruvat dehidrogenase''' ({{lang-en|pyruvate dehydrogenase complex, PDC}}) adalah sekelompok [[enzim]] [[dehidrogenase]] dengan [[massa]] sekitar
| url = http://www.sciencemag.org/cgi/content/abstract/255/5051/1544
| title = Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex
| accessdate = 2010-11-03
| work = Department of Chemistry, University of Groningen; A Mattevi, G Obmolova, E Schulze, KH Kalk, AH Westphal, A de Kok, dan WG Hol
}}</ref> yang mengkonversi [[asam piruvat]] menjadi [[asetil-KoA]] melalui [[reaksi kimia|reaksi organik]] yang disebut [[dekarboksilasi]] oksidatif piruvat. Reaksi yang terjadi adalah di dalam [[mitokondria]] adalah,<ref>{{en}}{{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879633
| title = Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3-binding protein of human pyruvate dehydrogenase complex
| accessdate = 2010-11-03
| work = Department of Biochemistry, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas; Chad A. Brautigam, R. Max Wynn, Jacinta L. Chuang, Mischa Machius, Diana R. Tomchick, dan David T. Chuang
}}</ref>
:[[asam piruvat|CH<sub>3</sub>-CO-COOH]] + [[Koenzim A|CoASH]] + [[nikotina adenosina dinukleotida|NAD<sup>+</sup>]] → [[Asetil-KoA|CH<sub>3</sub>-CO-S-CoA]] + [[karbon dioksida|CO<sub>2</sub>]] + NADH + H<sup>+</sup>
Pada [[mamalia]], PDC terdiri dari sekitar 60 [[monomer]] [[dihidrolipoamida asetiltransferase]], 30 monomer [[piruvat dekarboksilase]] dan 6 monomer [[dihidrolipoamida dehidrogenase]].<ref>{{en}}{{cite web
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