[[Berkas:Main complications of persistent high blood pressure.svg|jmpl|Diagram menggambarkan komplikasi utama tekanan darah tinggi persisten.]]
Hipertensi adalahmerupakan faktor risiko yang bisa dicegah yang terpenting bagi kematian prematur di seluruh dunia.<ref>{{cite web|title= Global health risks: mortality and burden of disease attributable to selected major risks.|url=http://www.who.int/healthinfo/global_burden_disease/GlobalHealthRisks_report_full.pdf|work=World Health Organization|year=2009|accessdate=10 February 2012}}</ref> Hipertensi meningkatkan risiko [[penyakit jantung iskemik]]<ref name=pmid12493255>{{cite journal |author=Lewington S, Clarke R, Qizilbash N, Peto R, Collins R |title=Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies |journal=Lancet |volume=360 |issue=9349 |pages=1903–13 |year=2002 |month=December |pmid=12493255 |doi= 10.1016/S0140-6736(02)11911-8|url=}}</ref> [[strokesstroke]],<ref name="ABC" /> [[penyakit periferal vaskular]],<ref name="pmid18375152">{{cite journal |author=Singer DR, Kite A |title=Management of hypertension in peripheral arterial disease: does the choice of drugs matter? |journal=European Journal of Vascular and Endovascular Surgery |volume=35 |issue=6 |pages=701–8 |year=2008 |month=June |pmid=18375152 |doi=10.1016/j.ejvs.2008.01.007}}</ref> dan penyakit kardiovaskular lain, termasuk [[gagal jantung]], [[aneurisma aorta]], [[aterosklerosis]] difus, dan [[emboli paru]].<ref name="ABC" /> Hipertensi juga merupakan faktor risiko terjadinya [[gangguan kognitif]], [[demensia]], dan [[penyakit ginjal kronik]].<ref name="ABC" />
Komplikasi lain di antaranya:
* [[Retinopati Hipertensihipertensi]]
* [[Nefropati hipertensi]]<ref name="pmid19330604">{{cite journal |author=Zeng C, Villar VA, Yu P, Zhou L, Jose PA |title=Reactive oxygen species and dopamine receptor function in essential hypertension |journal=Clinical and Experimental Hypertension |volume=31 |issue=2 |pages=156–78 |year=2009 |month=April |pmid=19330604 |doi=10.1080/10641960802621283}}</ref>
