Favipiravir: Perbedaan antara revisi

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'''Favipiravir''', atau yang dikenal dengan nama '''Avigan''' dan '''favilavir''' adalah [[obat antivirus]] yang dikembangkan oleh [[ FUJIFILM Toyama Chemical Co, Ltd |Toyama Chemical]] (anak perusahaan [[Fujifilm]]). Obat ini memiliki aktivitas melawan berbagai [[virus RNA]]. Senyawa antivirus ini merupakan turunan dari [[Pirazinamid|pirazinkarboksamida]]. Dalam percobaan yang dilakukan pada hewan, Favipiravir menunjukkan adanya aktivitas melawan [[Orthomyxoviridae|virus influenza]], [[virus West Nile]], [[Demam kuning|virus demam kuning]], [[Virus penyakit mulut dan kuku|virus penyakit mulut dan kuku,]][[flavivirus]], [[ Arenavirus |arenavirus]], [[ Bunyavirus |bunyavirus]], dan [[ Alphavirus |alphavirus]].<ref name="Furuta">{{Cite journal|date=Juni 2009|title=T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections|journal=Antiviral Research|volume=82|issue=3|pages=95–102|doi=10.1016/j.antiviral.2009.02.198|pmc=|pmid=19428599|vauthors=Furuta Y, Takahashi K, Shiraki K, Sakamoto K, Smee DF, Barnard DL, Gowen BB, Julander JG, Morrey JD}}</ref> Selain itu, Favipiravir juga menunjukkan adanya aktivitas melawan [[ Enterovirus |enterovirus]]<ref name="Furuta2013">{{Cite journal|date=November 2013|title=Favipiravir (T-705), a novel viral RNA polymerase inhibitor|journal=Antiviral Research|volume=100|issue=2|pages=446–54|doi=10.1016/j.antiviral.2013.09.015|pmc=3880838|pmid=24084488|vauthors=Furuta Y, Gowen BB, Takahashi K, Shiraki K, Smee DF, Barnard DL}}</ref> dan virus [[demam lembah rift]].<ref>{{Cite journal|date=April 2014|title=Broad spectrum antiviral activity of favipiravir (T-705): protection from highly lethal inhalational Rift Valley Fever|journal=PLoS Neglected Tropical Diseases|volume=8|issue=4|pages=e2790|doi=10.1371/journal.pntd.0002790|pmc=3983105|pmid=24722586|vauthors=Caroline AL, Powell DS, Bethel LM, Oury TD, Reed DS, Hartman AL}}</ref> Favipiravir juga memiliki efektivitas yang terbatas terhadap [[virus Zika]] dalam penelitian pada hewan.<ref>{{Cite journal|year=2016|title=Zika Virus: Where Is the Treatment?|journal=Current Treatment Options in Infectious Diseases|volume=8|issue=3|pages=208–11|doi=10.1007/s40506-016-0083-7|pmc=4969322|pmid=27547128|vauthors=Mumtaz N, van Kampen JJ, Reusken CB, Boucher CA, Koopmans MP}}</ref> Obat ini juga menunjukkan efektivitas melawan [[rabies]].<ref>{{Cite journal|date=April 2016|title=Efficacy of Favipiravir (T-705) in Rabies Postexposure Prophylaxis|journal=The Journal of Infectious Diseases|volume=213|issue=8|pages=1253–61|doi=10.1093/infdis/jiv586|pmc=4799667|pmid=26655300|vauthors=Yamada K, Noguchi K, Komeno T, Furuta Y, Nishizono A}}</ref> Favipiravir telah digunakan secara eksperimental pada beberapa pasien yang terinfeksi virus.<ref>{{Cite journal|date=Januari 2019|title=Human Rabies - Virginia, 2017|journal=MMWR. Morbidity and Mortality Weekly Report|language=en-us|volume=67|issue=5152|pages=1410–14|doi=10.15585/mmwr.mm675152a2|pmc=6334827|pmid=30605446|vauthors=Murphy J, Sifri CD, Pruitt R, Hornberger M, Bonds D, Blanton J, Ellison J, Cagnina RE, Enfield KB, Shiferaw M, Gigante C, Condori E, Gruszynski K, Wallace RM}}</ref>
 
Pada Februari 2020, Favipiravir sedang diteliti di Tiongkok sebagai pengobatan terhadap [[penyakit koronavirus 2019]].<ref>Li G, De Clercq E. Therapeutic options for the 2019 novel coronavirus (2019-nCoV). ''Nature Reviews Drug Discovery'' 2020 Feb {{Doi|10.1038/d41573-020-00016-0}}</ref><ref>[https://www.reuters.com/article/brief-corrected-zhejiang-hisun-pharma-ge/brief-corrected-zhejiang-hisun-pharma-gets-approval-for-clinical-trial-to-test-flu-drug-favipiravir-for-pneumonia-caused-by-new-coronavirus-idUSL4N2AH0C8 BRIEF-Corrected-Zhejiang Hisun Pharma gets approval for clinical trial to test flu drug Favipiravir for pneumonia caused by new coronavirus]. Reuters Healthcare, 20 Maret 2020.</ref> Pada 17 Maret, pejabat pemerintah Tiongkok mengatakan bahwa Favipiravir efektif dalam mengobati penyakit koronavirus di Wuhan dan Shenzhen.<ref>[https://www3.nhk.or.jp/nhkworld/en/news/20200317_48/ NHK World News ‘China: Avigan effective in tackling coronavirus’]</ref><ref>[http://www.xinhuanet.com/english/2020-03/17/c_138887971.htm Huaxia. "Favipiravir shows good clinical efficacy in treating COVID-19: official." Xinhuanet.com, 17 Maret 2020]</ref>