Metaloprotease: Perbedaan antara revisi
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== Metaloproteinase matriks ==
[[Metaloproteinase matriks]], atau MMP, sesuai dengan namanya, merupakan [[protease]] dengan aktivitas degradasi terhadap [[protein]] [[jaringan ikat]] seperti [[kolagen]], [[elastin]], [[proteoglikan]] dan [[laminin]].<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246078
| title = Control of Matrix Metalloproteinase Catalytic Activity
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}}</ref> Pada semua [[organisme]], MMP merupakan [[endopeptidase]] yang mengandung domain aktif [[seng|Zn]]<sup>2+</sup> dan terbagi ke dalam klasifikasi menurut struktur domain [[katalis|katalitik]]. Seperti, MMP metzincin dengan karakter berupa motif ikat Zn berupa 3-[[histidina]] dan [[methionina]]. Anggota MMP metzincin meliputi [[reprolisin]], [[seralisin]], [[astacin]], [[matriksin]] atau metaloproteinase matriks; MMP.
MMP telah dikenal perannya dalam pertumbuhan [[sel kanker]] dan [[metastasis]],<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/11990853
| title = New functions for the matrix metalloproteinases in cancer progression.
| accessdate = 2010-12-04
| work = Department of Anatomy, University of California at San Francisco; Egeblad M, Werb Z.
}}</ref> pada [[kanker payudara]], [[kanker usus besar|usus besar]], dan [[kanker pankreas|pankreas]],<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639045
| title = Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2
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| work = Department of Pharmacology and Cancer Biology, Department of Medicine, Duke University; Kelly J. Gordon, Kellye C. Kirkbride, Tam How, dan Gerard C. Blobe
| quote = MMPs have been implicated in facilitating the invasion and metastasis of breast, colon and pancreatic cancers
}}</ref> dan telah sering menjadi target terapi anti kanker,<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/11923519
| title = Matrix metalloproteinase inhibitors and cancer: trials and tribulations.
| accessdate = 2010-12-04
| work = Department of Pathology and Cancer Research Institute, University of California; Coussens LM, Fingleton B, Matrisian LM.
}}</ref> oleh karena ekspresinya yang berlebih.<ref>{{en}} {{cite web
| url = http://www.ncbi.nlm.nih.gov/pubmed/12908552
| title = Matrix metalloproteinases and tumor progression.
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