Serotonin: Perbedaan revisi

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<tr><th colspan="2" align=center bgcolor="#cccccc">'''Serotonin'''</th></tr>
<tr><td colspan="2" align="center">[[ImageBerkas:Serotonin-skeletal.png|145px|Struktur kimia serotonin]][[ImageBerkas:Serotonin-3D-vdW.png|145px|Struktur tiga dimensi ]]</td></tr>
<tr><td>[[Nomenklatur IUPAC|Nama kimia]]</td><td>5-Hydroxytryptamine or<br />3-(2-aminoethyl)-1''H''-indol-5-ol</td></tr>
<tr><td>[[Rumusan kimia]]</td><td>N<sub>2</sub>O<sub></sub>C<sub>10</sub>H<sub>12</sub></td></tr>
<tr><td>[[Massa monoisotop]]</td><td>176.0950 g/mol</td></tr>
<tr><td>Komposisi (berat)</td><td>N: 15.8970% &nbsp;O: 9.0793%<br />C: 68.1598% &nbsp;H: 6.8638%</td></tr>
<tr><td>[[Nomor registrasi CAS|Nomor CAS]]</td><td>50-67-9</td></tr>
<tr><td>[[Kode SMILES|SMILES]]</td><td><small>NCCC1=CNC2=C1C=C(O)C=C2</small></td></tr>
<tr><td>[[InChI|IUPAC InChI ID]]</td><td><small>1/C10H12N2O/c11-4-3-7-6-12-10-2-1-<br />8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2</small></td></tr>
'''Serotonin''' ('''5-hydroxytryptamine''', atau '''5-HT''') adalah suatu [[neurotransmitter]] [[monoamino]] yang disintesiskan dalam [[neuron]]-neuron serotonergis dalam [[sistem saraf pusat]] (CNS) dan [[sel (biologi)|sel]]-sel [[enterochromaffin]] dalam [[saluran pencernaan]].
<!--In the CNS, serotonin is believed to play an important role in the regulation of [[mood]], [[sleep]], [[emesis]] (vomiting), [[Human sexual behavior|sexuality]] and [[appetite]]. Serotonin has been thought to play a part in many disorders, notably as part of the [[biochemistry]] of [[Clinical depression|depression]], [[migraine]], [[bipolar disorder]] and [[anxiety]]. Recent research suggests that serotonin also plays an important role in [[liver]] regeneration and acts as a [[mitogen]] (induces cell division) throughout the body.<ref>{{cite journal
| volume = 312
| issue = 5770
| pages = 104&ndash;7104–7
| id = PMID 16601191
Isolated and named in [[1948]] by Maurice M. Rapport, the name "serotonin" is something of a misnomer and reflects the circumstances of the compound's discovery. It was initially identified as a vasoconstrictor substance in blood serum &mdash; hence ''serotonin'', a serum agent affecting vascular tone. This agent was later chemically identified as 5-hydroxytryptamine (5-HT) by Rapport, and, as the broad range of physiological roles were elucidated, 5-HT became the preferred name in the pharmacological field.
Serotonin is found extensively in the human [[gastrointestinal tract]] (about 90% []), as well as in the blood stream.
In the body, serotonin is synthesized from the [[amino acid]] [[tryptophan]] by a short [[metabolic pathway]] consisting of two [[enzyme]]s &mdash; TPH([[Tryptophan hydroxylase 1|1]],[[Tryptophan hydroxylase 2|2]]) and [[Aromatic-L-amino-acid decarboxylase|DDC]]. TPH1 [[chemical reaction|reaction]] controls the flux through the pathway.
<br />
| volume = 311
| issue = 5757
| pages = 77&ndash;8077–80
| id = PMID 16400147
===Serotonin syndrome===
Care must be taken in any attempt to increase serotonin levels, as a dangerous condition known as [[serotonin syndrome]] may result. This is especially a concern if multiple serotonergic agents [[interaction|interact]] to increase 5-HT levels &mdash; such as can happen when an [[MAOI]] is taken in combination with an [[SSRI]].
[[Category:Amino biogenis]]
[[CategoryKategori:Amino biogenis]]