Peran kameo dalam film ini antara lain [[Bryan Cranston]],<ref>{{cite web|last1=Thomas|first1=Sarah|title=Bryan Cranston's surprise new cameo role harks back to Malcolm in the Middle|url=http://www.smh.com.au/entertainment/movies/bryan-cranstons-surprise-new-cameo-role-harks-back-to-malcolm-in-the-middle-20161102-gsgi9n.html|website=smh.com|publisher=The Sydney Morning Herald|accessdate=21 December 2016|date=2 November 2016}}</ref> [[Zach Braff]], [[J. J. Abrams]], [[David DeCoteau]], [[Lizzy Caplan]], [[Kristen Bell]], [[Keegan-Michael Key]], [[Adam Scott (actoraktor)|Adam Scott]], [[Danny McBride]], [[Judd Apatow]]<ref>{{Cite news|url=http://ew.com/movies/2017/03/13/the-disaster-artist-sxsw/|title=James Franco's 'The Room' Movie Receives Standing Ovation at SXSW|last=Rosen|first=Christopher|date=March 13, 2017|work=Entertainment Weekly|access-date=June 9, 2017|archive-url=|archive-date=|dead-url=|language=en-US}}</ref> anddan [[Angelyne]] sebagai diri sendiri dan Tommy Wiseau sebagai Henry.<ref>{{cite web|last1=Chitwood|first1=Adam|title=‘The Disaster Artist’: James Franco Reveals Tommy Wiseau Has a Contractually Obligated Cameo|url=http://collider.com/the-disaster-artist-james-franco-tommy-wiseau-cameo/|website=collider.com|publisher=[[Complex Media]]|accessdate=21 December 2016|date=22 March 2016}}</ref><ref>{{cite web|last1=Wagmaster|first1=Elizabeth|title=‘Freaks and Geeks’ Reboot? Judd Apatow Teases ‘Anything Can Happen’|url=https://variety.com/2016/tv/news/freaks-and-geeks-reboot-judd-apatow-1201681783/|website=''[[Variety (magazine)|Variety]]''|accessdate=2 February 2016}}</ref>
