Pada tahun 2004 Bowie menerima ketakutan kesehatan utama ketika ia mengalami serangan jantung saat di atas panggung di Jerman. Dia meninggal dunia pada tanggal 10 Januari 2016 setelah berjuang melawan penyakit kanker yang dideritanya selama 18 bulan.<ref>{{cite web|url=http://news.sky.com/story/1620422/david-bowie-has-died-from-cancer-son|accessdate=11 January 2016|date=11 January 2016|work=News Sky|title=David Bowie Has Died From Cancer: Son}}</ref><ref>{{Cite web|title = Music legend David Bowie dies|url = http://www.bbc.co.uk/news/entertainment-arts-35278872|website=BBC News|accessdate=11 January 2016}}</ref><ref>{{Cite web|title=David Bowie dies aged 69 after 18-month battle with cancer|url = http://www.theverge.com/2016/1/11/10747734/david-bowie-dies-age-69-cancer|work=[[The Verge]]|publisher=[[Vox Media]]|accessdate=11 January 2016}}</ref><ref>{{cite web|url=http://www.hollywoodreporter.com/news/david-bowie-dead-legendary-artist-854364|work=[[The Hollywood Reporter]]|publisher=[[Prometheus Global Media]]|accessdate=11 January 2016|date=11 January 2016|title=Legendary Artist David Bowie Dies at 69|first=Mike|last=Barnes}}</ref><ref>{{Cite news|title = David Bowie, the Legendary Musician, Has Died at 69|url = http://www.nytimes.com/2016/01/12/arts/music/david-bowie-dies-at-69.html|newspaper = The New York Times|date = 2016-01-11|access-date = 2016-01-11|issn = 0362-4331}}</ref><ref>{{Cite web|title = David Bowie dies at the age of 69|url = http://www.theguardian.com/music/2016/jan/11/david-bowie-dies-at-the-age-of-69|website = the Guardian|accessdate = 2016-01-11|first = Guardian|last = Music}}</ref><ref>{{Cite news|title = David Bowie dies after 18-month battle with cancer|url = http://www.reuters.com/article/us-people-bowie-death-idUSKCN0UP0KD20160111|newspaper = Reuters|date = 2016-01-11|access-date = 2016-01-11}}</ref>
