'''MDMA''' ('''3,4-[[metil|metilen]]en[[oksigen|dioksi]]-[[metamfetamina]]'''), biasanya dikenal dengan nama '''Ekstasi''', '''E''', '''X''', atau '''XTC'''<ref name="nature.com">{{cite journal|last1=Luciano|first1=Randy L.|last2=Perazella|first2=Mark A.|title=Nephrotoxic effects of designer drugs: synthetic is not better!|journal=Nature Reviews Nephrology|date=25 March 2014|volume=10|issue=6|pages=314–324|doi=10.1038/nrneph.2014.44|url=http://www.nature.com/nrneph/journal/v10/n6/abs/nrneph.2014.44.html|accessdate=2 December 2014}}</ref><ref name=DrugFacts>{{cite web|title=DrugFacts: MDMA (Ecstasy or Molly)|url=http://www.drugabuse.gov/publications/drugfacts/mdma-ecstasy-or-molly|publisher=National Institute on Drug Abuse|accessdate=2 December 2014}}</ref> adalah senyawa kimia yang sering digunakan sebagai obat rekreasi yang membuat penggunanya menjadi sangat aktif.<ref name=Current2013/><ref name="Acute amph toxicity" /><ref name=Drugs2014/><!-- Quote = producing an energizing effect, as well as distortions in time and perception and enhanced enjoyment from tactile experiences --> Ketika dimasukkan lewat mulut, efek obat ini akan kambuh pada 30–45 menit dan berakhir 3–6 jam.<ref name=Freye2009>{{cite book|last1=Freye|first1=Enno|title=Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs|date=28 July 2009|publisher=Springer Netherlands|isbn=978-90-481-2448-0|pages=151–160|url=http://link.springer.com/chapter/10.1007/978-90-481-2448-0_24|accessdate=18 June 2015|chapter=Pharmacological Effects of MDMA in Man}}</ref><ref name=NIH2016/>Obat ini juga terkadang dimasukkan melalui hidung atau diasapkan.<ref name=Drugs2014>{{cite web|title=MDMA|url=http://www.drugs.com/illicit/mdma.html|accessdate=30 March 2016|editor-last=Anderson|editor-first=Leigh|website=Drugs.com|publisher=Drugsite Trust|date=18 May 2014}}</ref> Sejak 2017, MDMA tidak menerima penggunaan medis.<ref name="EMCDDA"/>
