AP-1: Perbedaan antara revisi

Dalam bidang studi [[genetika]], '''AP-1''' ({{lang-en|activator protein 1, AP-1}}) adalah [[protein]] di dalam [[inti sel]] berbentuk heterodimerik dari kompleks [[fos]], [[jun]]<ref>{{en}} {{cite web|url=http://www.ncbi.nlm.nih.gov/pubmed/14585541|title=A role for AP-1 in apoptosis: the case for and against|accessdate=2010-09-18|work=Department of Developmental Biology, Fernbach Building, Institut Pasteur; Ameyar M, Wisniewska M, Weitzman JB.}}</ref> dan subgroup [[ATF]],<ref>{{en}} {{cite web|url=http://www.ncbi.nlm.nih.gov//pubmed/11402335|title=AP-1 in cell proliferation and survival|accessdate=2010-09-18|work=Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego; Shaulian E, Karin M.}}</ref> yang merupakan [[faktor transkripsi]] yang memiliki peran penting dalam ekspresi genetik selularseluler seperti [[transformasi]], [[proliferasi]] melalui represi ekspresi gen supresor [[tumor]], [[diferensiasi]], [[apoptosis]], migrasi [[sel (biologi)|sel]];<ref>{{en}} {{cite web|url=http://www.ncbi.nlm.nih.gov/pubmed/20060892|title=AP-1--The Jun proteins: Oncogenes or tumor suppressors in disguise?|accessdate=2010-09-18|work=Department of Biochemistry and Molecular Biology, The Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School; Shaulian E.}}</ref> mengendalikan ekspresi dan fungsi regulator [[siklus sel]] seperti siklin D1, supresor tumor p53, p21(cip1/waf1), p19(ARF) dan p16; dan [[peradangan]].