Rhodopsin: Perbedaan antara revisi

[[FileBerkas:Rhodopsin-transducin.png|thumb|250px|Rhodopsin]]

Rhodopsin masuk dalam keluarga reseptor protein berpasangan G dan sangat sensitiv terhadap cahaya, yang mampu menangkap cahaya yang rendah.<ref name="Litmann_1996">{{cite book|author = Litmann BJ, Mitchell DC|authorlink =|editor = Lee AG|others =|title = Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set)|edition =|language =|publisher = JAI Press|location = Greenwich, Conn|year = 1996|origyear =|pages = 1–32|quote =|isbn = 1-55938-659-2|chapter = Rhodopsin structure and function|doi =|url =|accessdate = }}</ref> Saat terkena cahaya, pigmennya akan segera mengalami [[fotoblecing]] dan manusia memerlukan waktu sekitar 30 menit untuk melakukan hal ini.<ref name="Stuart_1996">{{cite book|author = Stuart JA, Brige RR|authorlink =|editor = Lee AG|others =|title = Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set)|edition =|language =|publisher = JAI Press|location = Greenwich, Conn|year = 1996|origyear =|pages = 33–140|quote =|isbn = 1-55938-659-2|chapter = Characterization of the primary photochemical events in bacteriorhodopsin and rhodopsin|doi =|url =|accessdate = }}</ref>

== Struktur ==

== Referensi ==

* {{en}} {{cite journal | author=Humphries P, Kenna P, Farrar GJ |title=On the molecular genetics of retinitis pigmentosa. |journal=Science |volume=256 |issue= 5058 |pages= 804–8 |year= 1992 |pmid= 1589761| doi=10.1126/science.1589761}}

* {{en}} {{cite journal | author=Edwards SC |title=Involvement of cGMP and calcium in the photoresponse in vertebrate photoreceptor cells. |journal=The Journal of the Florida Medical Association |volume=82 |issue= 7 |pages= 485–8 |year= 1995 |pmid= 7673885 |doi= }}

* {{en}} {{cite journal | author=al-Maghtheh M, Gregory C, Inglehearn C, ''et al.'' |title=Rhodopsin mutations in autosomal dominant retinitis pigmentosa. |journal=Hum. Mutat. |volume=2 |issue= 4 |pages= 249–55 |year= 1993 |pmid= 8401533 |doi= 10.1002/humu.1380020403 }}

* {{en}} {{cite journal | author=Garriga P, Manyosa J |title=The eye photoreceptor protein rhodopsin. Structural implications for retinal disease. |journal=FEBS Lett. |volume=528 |issue= 1–3 |pages= 17–22 |year= 2002 |pmid= 12297272| doi=10.1016/S0014-5793(02)03241-6}}

* {{en}} {{cite journal | author=Mendes HF, van der Spuy J, Chapple JP, Cheetham ME |title=Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy |journal=Trends in molecular medicine |volume=11 |issue= 4 |pages= 177–85 |year= 2005 |pmid= 15823756 |doi= 10.1016/j.molmed.2005.02.007 }}

* {{en}} {{cite journal | author=Inglehearn CF, Keen TJ, Bashir R, ''et al.'' |title=A completed screen for mutations of the rhodopsin gene in a panel of patients with autosomal dominant retinitis pigmentosa |journal=Hum. Mol. Genet. |volume=1 |issue= 1 |pages= 41–5 |year= 1993 |pmid= 1301135 |doi=10.1093/hmg/1.1.41 }}

* {{en}} {{cite journal | author=Farrar GJ, Findlay JB, Kumar-Singh R, ''et al.'' |title=Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family |journal=Hum. Mol. Genet. |volume=1 |issue= 9 |pages= 769–71 |year= 1993 |pmid= 1302614 |doi=10.1093/hmg/1.9.769 }}

* {{en}} {{cite journal | author=Robinson PR, Cohen GB, Zhukovsky EA, Oprian DD |title=Constitutively active mutants of rhodopsin |journal=Neuron |volume=9 |issue= 4 |pages= 719–25 |year= 1992 |pmid= 1356370| doi=10.1016/0896-6273(92)90034-B}}

* {{en}} {{cite journal | author=Fujiki K, Hotta Y, Hayakawa M, ''et al.'' |title=Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP) |journal=Jpn. J. Hum. Genet. |volume=37 |issue= 2 |pages= 125–32 |year= 1992 |pmid= 1391967| doi=10.1007/BF01899733}}

* {{en}} {{cite journal | author=Olsson JE, Gordon JW, Pawlyk BS, ''et al.'' |title=Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa |journal=Neuron |volume=9 |issue= 5 |pages= 815–30 |year= 1992 |pmid= 1418997| doi=10.1016/0896-6273(92)90236-7}}

* {{en}} {{cite journal | author=Andréasson S, Ehinger B, Abrahamson M, Fex G |title=A six-generation family with autosomal dominant retinitis pigmentosa and a rhodopsin gene mutation (arginine-135-leucine) |journal=Ophthalmic paediatrics and genetics |volume=13 |issue= 3 |pages= 145–53 |year= 1993 |pmid= 1484692 |doi=10.3109/13816819209046483 }}

* {{en}} {{cite journal | author=Inglehearn CF, Lester DH, Bashir R, ''et al.'' |title=Recombination between rhodopsin and locus D3S47 (C17) in rhodopsin retinitis pigmentosa families |journal=Am. J. Hum. Genet. |volume=50 |issue= 3 |pages= 590–7 |year= 1992 |pmid= 1539595 |doi= | pmc=1684283 }}

* {{en}} {{cite journal | author=Fishman GA, Stone EM, Gilbert LD, Sheffield VC |title=Ocular findings associated with a rhodopsin gene codon 106 mutation. Glycine-to-arginine change in autosomal dominant retinitis pigmentosa |journal=Arch. Ophthalmol. |volume=110 |issue= 5 |pages= 646–53 |year= 1992 |pmid= 1580841 |doi= }}

* {{en}} {{cite journal | author=Keen TJ, Inglehearn CF, Lester DH, ''et al.'' |title=Autosomal dominant retinitis pigmentosa: four new mutations in rhodopsin, one of them in the retinal attachment site |journal=Genomics |volume=11 |issue= 1 |pages= 199–205 |year= 1992 |pmid= 1765377 |doi=10.1016/0888-7543(91)90119-Y }}

* {{en}} {{cite journal | author=Dryja TP, Hahn LB, Cowley GS, ''et al.'' |title=Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 9370–4 |year= 1991 |pmid= 1833777| doi=10.1073/pnas.88.20.9370 | pmc=52716}}

* {{en}} {{cite journal | author=Gal A, Artlich A, Ludwig M, ''et al.'' |title=Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa |journal=Genomics |volume=11 |issue= 2 |pages= 468–70 |year= 1992 |pmid= 1840561 |doi=10.1016/0888-7543(91)90159-C }}

* {{en}} {{cite journal | author=Sung CH, Davenport CM, Hennessey JC, ''et al.'' |title=Rhodopsin mutations in autosomal dominant retinitis pigmentosa |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 15 |pages= 6481–5 |year= 1991 |pmid= 1862076 |doi=10.1073/pnas.88.15.6481 | pmc=52109 }}

* {{en}} {{cite journal | author=Jacobson SG, Kemp CM, Sung CH, Nathans J |title=Retinal function and rhodopsin levels in autosomal dominant retinitis pigmentosa with rhodopsin mutations |journal=Am. J. Ophthalmol. |volume=112 |issue= 3 |pages= 256–71 |year= 1991 |pmid= 1882937 |doi= }}

* {{en}} {{cite journal | author=Sheffield VC, Fishman GA, Beck JS, ''et al.'' |title=Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis |journal=Am. J. Hum. Genet. |volume=49 |issue= 4 |pages= 699–706 |year= 1991 |pmid= 1897520 |doi= | pmc=1683182 }}