Aprikoksib

Aprikoksib
Nama sistematis (IUPAC)
	4-[2-(4-Ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]benzenesulfonamide
Data klinis
Kat. kehamilan	?
Status hukum	?
Pengenal
Nomor CAS	162011-90-7
Kode ATC	?
PubChem	CID 9820073
ChemSpider	7995822
UNII	5X5HB3VZ3Z
KEGG	D08657
Data kimia
Rumus	C19H20N2O3S
SMILES	eMolecules & PubChem
	InChI InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23); Key:JTMITOKKUMVWRT-UHFFFAOYSA-N;

Aprikoksib merupakan obat antikanker eksperimental. Aprikoksib digolongkan sebagai inhibitor COX-2 yang digunakan untuk meningkatkan respon pengobatan pada penyakit kanker pankreas.^[1] Pengembangan aprikoksib dihentikan pada tahun 2015 dikarenakan hasil uji klinik yang cukup buruk.^[2]

Referensi sunting

^ Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, et al. (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer". Clinical Cancer Research. 18 (18): 5031–42. doi:10.1158/1078-0432.CCR-12-0453. PMC 3777527  . PMID 22829202.
^ "Apricoxib". Adis Insight. Springer Nature Switzerland AG.

[1] Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, et al. (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer". Clinical Cancer Research. 18 (18): 5031–42. doi:10.1158/1078-0432.CCR-12-0453. PMC 3777527  . PMID 22829202.

[2] "Apricoxib". Adis Insight. Springer Nature Switzerland AG.

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